The characteristic unpleasant smell and low odour threshold (0.1 ppm; 0.43 mg/m3) allows styrene to be readily detected in the workplace at levels below the occupational exposure standards. (Birth Defects Research Part B: Developmental and Reproductive Toxicity, 2005). Styrene 100- 42 -5 90 - 100% Yes 3. Tests for reproductive toxicity have given negative results, but effects on blood dopamine and hypothalamic and pituitary function and menstrual cycling under conditions of very high exposure have been reported. Toluene is also used as a solvent for paints, lacquers, and adhesives. In rabbits exposed to styrene ... ated the reproductive toxicity of ethylene oxide, propylene oxide, butylene oxide, and styrene oxide. Hazards Identification Emergency Overview ----- DANGER! Detailed results of these studies are available from the National Institute for Occupational Safety Reports of organ toxicity upon chronic exposure to styrene are rare; however, since the chief intermediate in styrene metabolism is an epoxide, hepatotoxicity due to covalent binding at the site of formation appears to be a possibility. styrene oxide, a finding suggesting preimplantation loss. Gary P. Carlson, Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice, Toxicology, 10.1016/j.tox.2012.02.006, 294, 2-3, (104-108), (2012). Chronic toxicity and reproductive performance were evaluated in groups of rats receiving styrene monomer in their drinking water at nominal concentrations of 0, 125, or 250 ppm. Female reproductive toxicity. There are good reasons that the reduction in grip strength is not an indication for a specific developmental effect but is rather attributable to a combination of reduced body weight and chance variations in data. Acute toxicity * Oral * Dermal * Inhalation Skin corrosion/irritation Serious eye damage/irritation Respiratory sensitization Skin sensitization Carcinogenicity * IARC * OSHA * ACGIH * NTP * EU CLP Germ cell mutagenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard noviembre 19, 2020; schließen Weitere Informationen über unsere Verwendung von Cookies. General information; Classification & Labelling & PBT assessment; Manufacture, use & exposure Developmental or reproductive toxicity studies have been conducted in rats, mice, rabbits, and hamsters. This study was conducted to evaluate the potential adverse effects of styrene on reproductive capability from whole‐body inhalation exposure of F 0 and F 1 parental animals. CATEGORY 2: Suspected human reproductive toxicant Substances are classified in Category 2 for reproductive toxicity when there is some evidence from humans or experimental animals, possibly supplemented with other information, of an adverse effect on sexual function and fertility, or on development, and where the evidence is not sufficiently convincing to place the substance in Category 1. 98-83-9. 2000 Is Peer Reviewed? 32 Issue. Extensive mortality occurred in rats that received prolonged exposure to 100 ppm styrene oxide while 300 ppm was rapidly lethal. HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. Toxicity Data 1) Information on adverse effects on human health There is no report on the effects on human health due to exposure to styrene dimer and trimer. Nonneoplastic lesions were observed in the brain, thymus, spleen, liver, kidney, and reproductive organs of males and females and were considered due to overt toxicity. Styrene will polymerise when contaminated by oxidising agents and most halides. An LC Acute toxicity, Inhalation (Category4), H332 Skin irritation (Category2), H315 Eye irritation (Category 2), H319 Reproductive toxicity (Category 2), H361d Specific target organ toxicity - repeated exposure (Category 1), H372 For the full text of the H-Statementsmentioned in this … In light of all the available information, it is concluded that migration of styrene … Yes Journal. 1984; NIOSH 1983). 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive … In animals, inhalation studies indicate that the acute toxicity of styrene is low to moderate. Reproductive and Developmental Toxicity of Toluene: A Review by James M. Donald,* Kim Hooper,* and Claudia ... styrene production and coke-oven operations (4,8). Regulatory Toxicology and Pharmacology ISSN: 0273-2300 EISSN: 1096-0295 Volume. The animal studies on styrene have diverse study designs and conclusions. Suspected human reproductive toxicant Specific target organ toxicity - single exposure No data available Specific target organ toxicity - repeated exposure Causes damage to organs through prolonged or repeated exposure. 3.2.1.1 Death There have been no reports of deaths in humans directly associated with exposure to styrene in the workplace (EPA 1985a; Gosselin et al. Reproductive Toxicity Risk Assessment Published on October 31, 1996, Federal Register 61(212):56274-56322 These guidelines replace two proposed guidelines: Proposed Guidelines for Female Reproductive Risk and Proposed Guidelines for Male Reproductive Risk, both dated June 30, 1988. A review of the developmental and reproductive toxicity of styrene Author(s) Brown, NA; Lamb, JC; Brown, SM; Neal, BH Year. IARC: 2B - Group 2B: Possibly carcinogenic to humans (Styrene) Reproductive toxicity Suspected of damaging the unborn child. July 2000; Endocrine Journal 47(3):343-7 47(3):343-7 ... We don’t know what causes most fertility problems, miscarriages, birth defects, and other reproductive problems. The listing of α-methyl styrene for the endpoint of female reproductive toxicity is effective July 29, 2011. known effects of inhalation exposure of humans and animals to styrene. Experiments were performed to evalute reproductive and developmental toxicology in rats and rabbits exposed to styrene oxide by inhalation. Article. These chemicals include styrene, methyl methacrylate, epoxy resins, vinyl chloride, and others. The reproductive and developmental toxicity of styrene has been studied in animals and humans. Assessments included gonadal function, estrous cyclicity, mating behavior, conception rate, gestation, parturition, lactation, and weaning in the F 0 and F 1 generations, and F 1 generation offspring growth and development. The acute toxicity of styrene appears to be unrelated to its biotransformation. 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